The Human Ubiquitin Conjugating Enzyme, UBE2E3, Is Required for Proliferation of Retinal Pigment Epithelial Cells | Zendy

Kendra S. Plafker | Zendy; Krysten M. Farjo | Zendy; Allan F. Wiechmann | Zendy; Scott M. Plafker | Zendy

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The Human Ubiquitin Conjugating Enzyme, UBE2E3, Is Required for Proliferation of Retinal Pigment Epithelial Cells

Author(s) -

Kendra S. Plafker,

Krysten M. Farjo,

Allan F. Wiechmann,

Scott M. Plafker

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.08-1698

Subject(s) - biology , cell growth , microbiology and biotechnology , retinal pigment epithelium , kinase , small interfering rna , cell cycle , cell culture , cell , retinal , transfection , biochemistry , genetics

Cell cycle progression is governed by the coordinated activities of kinases, phosphatases, and the ubiquitin system. The entire complement of ubiquitin pathway components that mediate this process in retinal pigment epithelial (RPE) cells remains to be identified. This study was undertaken to determine whether the human ubiquitin-conjugating enzyme, UBE2E3, is essential for RPE cell proliferation.

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