Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover | Zendy

Mini Aga | Zendy; John M. Bradley | Zendy; Kate E. Keller | Zendy; Mary J. Kelley | Zendy; Ted S. Acott | Zendy

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Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover

Author(s) -

Mini Aga,

John M. Bradley,

Kate E. Keller,

Mary J. Kelley,

Ted S. Acott

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-1666

Subject(s) - invadopodia , extracellular matrix , colocalization , podosome , microbiology and biotechnology , fibronectin , trabecular meshwork , cortactin , focal adhesion , chemistry , matrix metalloproteinase , laminin , biophysics , cell , biology , biochemistry , cytoskeleton , signal transduction , genetics , cancer , neuroscience , cancer cell , glaucoma

There are distinctive areas of colocalization of matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes or invadopodia. Studies were conducted to determine whether TM cells exhibit podosome- or invadopodia-like structures (PILS) and whether they produce focal extracellular matrix (ECM) turnover.

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