A Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy | Zendy

Celia S. Chen | Zendy; Mary A. Johnson | Zendy; R. A. Flower | Zendy; Bernard J. Slater | Zendy; Neil R. Miller | Zendy; Steven L. Bernstein | Zendy

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A Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy

Author(s) -

Celia S. Chen,

Mary A. Johnson,

R. A. Flower,

Bernard J. Slater,

Neil R. Miller,

Steven L. Bernstein

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-1651

Subject(s) - anterior ischemic optic neuropathy , medicine , optic neuropathy , optic nerve , pathology , ischemia , magnetic resonance imaging , ophthalmology , radiology

Nonarteritic anterior ischemic optic neuropathy (NAION) is an optic nerve (ON) stroke and a leading cause of sudden ON-related vision loss. A primate (p)NAION model is crucial to further understanding of the clinical disorder and can provide information regarding the pathophysiology of other central nervous system (CNS) ischemic axonopathies. In the current study, a primate model of NAION was developed, and short-and long-term responses to this condition were characterized.

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