VIP and VIP Gene Silencing Modulation of Differentiation Marker N-Cadherin and Cell Shape of Corneal Endothelium in Human Corneas Ex Vivo | Zendy

ShayWhey M. Koh | Zendy; Krish Chandrasekara | Zendy; Cara J. Abbondandolo | Zendy; Timothy J. Coll | Zendy; Allan R. Rutzen | Zendy

Open Access

VIP and VIP Gene Silencing Modulation of Differentiation Marker N-Cadherin and Cell Shape of Corneal Endothelium in Human Corneas Ex Vivo

Author(s) -

ShayWhey M. Koh,

Krish Chandrasekara,

Cara J. Abbondandolo,

Timothy J. Coll,

Allan R. Rutzen

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-1543

Subject(s) - ex vivo , gene silencing , cadherin , corneal endothelium , microbiology and biotechnology , endothelium , in vivo , biology , cell , gene , endocrinology , genetics

Vasoactive intestinal peptide (VIP) is expressed by corneal endothelial (CE) cells and is present in the aqueous humor, which bathes CE cells in vivo. This study demonstrated the role of CE cell VIP in maintaining the expression level of a CE differentiation marker, N-cadherin, and the hexagonal cell shape.

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