Open AccessA High-Resolution RNA Expression Atlas of Retinitis Pigmentosa Genes in Human and Mouse Retinas
Author(s) -
Dragana Trifunović,
Marianthi Karali,
Davide Camposampiero,
Diego Ponzin,
Sandro Banfi,
Valeria Marigo
Publication year - 2008
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.07-1513
Subject(s) - biology , retinitis pigmentosa , gene , genetics , gene expression , rna , population , retina , neuroscience , medicine , environmental health
Retinitis pigmentosa (RP) is one of the leading causes of visual handicap in the world population and is characterized by high genetic heterogeneity. The study of the disease mechanisms and the development of efficient therapeutic approaches have mostly relied on the availability of animal models for this condition, so far. Nevertheless, little information is available about the RNA expression profiles of RP genes in the human retina. An expression atlas of 34 known RP genes in human and murine retinas was generated to overcome this lack of information.