Open AccessEssential Roles of the PI3 Kinase/Akt Pathway in Regulating Nrf2-Dependent Antioxidant Functions in the RPE
Author(s) -
Ling Wang,
Yan Chen,
Paul W. Sternberg,
Jiyang Cai
Publication year - 2008
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.07-1099
Subject(s) - wortmannin , protein kinase b , pi3k/akt/mtor pathway , glutathione , ly294002 , microbiology and biotechnology , chemistry , gclc , biology , phosphorylation , signal transduction , biochemistry , enzyme
To investigate functional interactions between the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent antioxidant system in cultured human retinal pigment epithelium (RPE) cells.
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