Expression of ZnT and ZIP Zinc Transporters in the Human RPE and Their Regulation by Neurotrophic Factors | Zendy

Kar Wah Leung | Zendy; Mugen Liu | Zendy; Xuming Xu | Zendy; Magdalene J. Seiler | Zendy; Colin J. Barnstable | Zendy; Joyce TombranTink | Zendy

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Expression of ZnT and ZIP Zinc Transporters in the Human RPE and Their Regulation by Neurotrophic Factors

Author(s) -

Kar Wah Leung,

Mugen Liu,

Xuming Xu,

Magdalene J. Seiler,

Colin J. Barnstable,

Joyce TombranTink

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-0781

Subject(s) - glial cell line derived neurotrophic factor , neurotrophic factors , pedf , western blot , ciliary neurotrophic factor , chemistry , neurotrophin , zinc , microbiology and biotechnology , biology , biochemistry , receptor , organic chemistry , gene , retinal

Zinc is an essential cofactor for normal cell function. Altered expression and function of zinc transporters may contribute to the pathogenesis of neurodegenerative disorders including macular degeneration. The expression and regulation of zinc transporters in the RPE and the toxicity of zinc to these cells were examined.

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