Cloning and Functional Characterization of the Proton-Coupled Electrogenic Folate Transporter and Analysis of Its Expression in Retinal Cell Types | Zendy

Nagavedi S. Umapathy | Zendy; Jaya P. GnanaPrakasam | Zendy; Pamela M. Martin | Zendy; Barbara A. Mysona | Zendy; Ying Dun | Zendy; Sylvia B. Smith | Zendy; Vadivel Ganapathy | Zendy; Puttur D. Prasad | Zendy

Open Access

Cloning and Functional Characterization of the Proton-Coupled Electrogenic Folate Transporter and Analysis of Its Expression in Retinal Cell Types

Author(s) -

Nagavedi S. Umapathy,

Jaya P. GnanaPrakasam,

Pamela M. Martin,

Barbara A. Mysona,

Ying Dun,

Sylvia B. Smith,

Vadivel Ganapathy,

Puttur D. Prasad

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-0288

Subject(s) - retina , xenopus , biology , in situ hybridization , microbiology and biotechnology , retinal , glut3 , gene expression , gene , biochemistry , glucose transporter , glut1 , endocrinology , neuroscience , insulin

In a prior study the cellular uptake of folate was investigated in the retina. Recently, a new proton-coupled folate transporter (PCFT) in human intestine was reported. In the present study, the expression of this novel transporter in the retina was determined, the mouse orthologue was cloned from retinal tissue, and its transport function was characterized.

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