The Role of Substance P in the Pathogenesis of Pterygia | Zendy

Jeanie Chui | Zendy; Nick Di Girolamo | Zendy; Minas T. Coroneo | Zendy; Denis Wakefield | Zendy

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The Role of Substance P in the Pathogenesis of Pterygia

Author(s) -

Jeanie Chui,

Nick Di Girolamo,

Minas T. Coroneo,

Denis Wakefield

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-0123

Subject(s) - pterygium , conjunctiva , receptor , substance p , cell migration , biology , epithelium , pathology , cell , microbiology and biotechnology , cancer research , immunology , medicine , neuropeptide , biochemistry , genetics

Pterygium is a prevalent ocular surface disorder thought to be triggered by chronic ultraviolet damage to the limbus. One of the enigmatic features of pterygium is its wing-like shape, and the mechanism(s) supporting its centripetal growth remain to be elucidated. Because the growth pattern of pterygia mirrors the radial arrangement of corneal nerves, the authors propose that neuropeptides may facilitate its directional growth. This hypothesis prompted an investigation of the role of the sensory neuropeptide substance P (SP) and its receptor (NK(1) receptor) in directing cell migration in pterygia that may explain the characteristic growth pattern.

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