Mecamylamine Suppresses Basal and Nicotine-Stimulated Choroidal Neovascularization | Zendy

Katsuji Kiuchi | Zendy; Masato Matsuoka | Zendy; Jenny Wu | Zendy; Raquel Lima e Silva | Zendy; Muralitharan Kengatharan | Zendy; Verghese Mary | Zendy; Shinji Ueno | Zendy; Katsutoshi Yokoi | Zendy; Naw Htee Khu | Zendy; John P. Cooke | Zendy; Peter A. Campochiaro | Zendy

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Mecamylamine Suppresses Basal and Nicotine-Stimulated Choroidal Neovascularization

Author(s) -

Katsuji Kiuchi,

Masato Matsuoka,

Jenny Wu,

Raquel Lima e Silva,

Muralitharan Kengatharan,

Verghese Mary,

Shinji Ueno,

Katsutoshi Yokoi,

Naw Htee Khu,

John P. Cooke,

Peter A. Campochiaro

Publication year - 2008

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-0089

Subject(s) - mecamylamine , choroidal neovascularization , nicotine , pharmacology , nicotinic agonist , nicotinic acetylcholine receptor , chemistry , medicine , macular degeneration , receptor , ophthalmology

Nicotinic acetylcholine receptors (nAChR) are best known for their role in neurotransmission, but they have recently been demonstrated on vascular endothelial cells. Acetylcholine is their endogenous ligand, but they are also stimulated by nicotine. By stimulating nAChR, nicotine promotes tumor angiogenesis as well as atherosclerotic plaque neovascularization. In this study, the authors investigated the role of nAChR in the pathogenesis of choroidal neovascularization (CNV).

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