MurineCcl2/Cx3cr1Deficiency Results in Retinal Lesions Mimicking Human Age-Related Macular Degeneration | Zendy

Jingsheng Tuo | Zendy; Christine M. Bojanowski | Zendy; Min Zhou | Zendy; Defen Shen | Zendy; Robert J. Ross | Zendy; Kevin I. Rosenberg | Zendy; D. Joshua Cameron | Zendy; Chunyue Yin | Zendy; Jeffrey A. Kowalak | Zendy; Zhengping Zhuang | Zendy; Kang Zhang | Zendy; ChiChao Chan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MurineCcl2/Cx3cr1Deficiency Results in Retinal Lesions Mimicking Human Age-Related Macular Degeneration

Author(s) -

Jingsheng Tuo,

Christine M. Bojanowski,

Min Zhou,

Defen Shen,

Robert J. Ross,

Kevin I. Rosenberg,

D. Joshua Cameron,

Chunyue Yin,

Jeffrey A. Kowalak,

Zhengping Zhuang,

Kang Zhang,

ChiChao Chan

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.07-0051

Subject(s) - cx3cr1 , macular degeneration , biology , retina , retinal degeneration , retinal pigment epithelium , retinal , endoplasmic reticulum , drusen , lipofuscin , neurodegeneration , pathology , ccl2 , microbiology and biotechnology , chemokine , medicine , immunology , neuroscience , inflammation , ophthalmology , biochemistry , chemokine receptor , disease

Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research