Global Changes in Optic Nerve Head Gene Expression after Exposure to Elevated Intraocular Pressure in a Rat Glaucoma Model | Zendy

Elaine C. Johnson | Zendy; Lijun Jia | Zendy; William O. Cepurna | Zendy; Thomas A. Doser | Zendy; John C. Morrison | Zendy

Open Access

Global Changes in Optic Nerve Head Gene Expression after Exposure to Elevated Intraocular Pressure in a Rat Glaucoma Model

Author(s) -

Elaine C. Johnson,

Lijun Jia,

William O. Cepurna,

Thomas A. Doser,

John C. Morrison

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-1282

Subject(s) - optic nerve , glaucoma , intraocular pressure , gene expression , tenascin c , optic disk , biology , ophthalmology , pathology , medicine , extracellular matrix , gene , microbiology and biotechnology , genetics

In glaucoma, the optic nerve head (ONH) is the likely site of initial injury and elevated intraocular pressure (IOP) is the best-known risk factor. This study determines global gene expression changes in the pressure-injured ONH.

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