Adenosine Opposes Thrombin-Induced Inhibition of Intercellular Calcium Wave in Corneal Endothelial Cells | Zendy

Catheleyne D’hondt | Zendy; Sangly P. Srinivas | Zendy; Johan Vereecke | Zendy; Bernard Himpens | Zendy

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Adenosine Opposes Thrombin-Induced Inhibition of Intercellular Calcium Wave in Corneal Endothelial Cells

Author(s) -

Catheleyne D’hondt,

Sangly P. Srinivas,

Johan Vereecke,

Bernard Himpens

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-1062

Subject(s) - lucifer yellow , microbiology and biotechnology , connexin , chemistry , adenosine , gap junction , biophysics , thrombin , myosin light chain kinase , intracellular , rhoa , heptanol , biochemistry , biology , signal transduction , myosin , immunology , platelet

In corneal endothelial cells, intercellular Ca(2+) waves elicited by a mechanical stimulus involve paracrine intercellular communication, mediated by ATP release via connexin hemichannels, as well as gap junctional intercellular communication. Both mechanisms are inhibited by thrombin, which activates RhoA and hence results in myosin light chain phosphorylation. This study was conducted to examine the effects of adenosine, which is known to oppose thrombin-induced RhoA activation, thereby leading to myosin light chain dephosphorylation, on gap junctional intercellular communication and paracrine intercellular communication in cultured bovine corneal endothelial cells.

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