Age-Related Cataracts in α3Cx46-Knockout Mice Are Dependent on a Calpain 3 Isoform | Zendy

Yajun Tang | Zendy; Xiangyang Liu | Zendy; Rebecca K. Zoltoski | Zendy; Layne A. Novak | Zendy; Raúl Herrera | Zendy; Isabelle Richard | Zendy; J.R. Kuszak | Zendy; Nalin M. Kumar | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Age-Related Cataracts in α3Cx46-Knockout Mice Are Dependent on a Calpain 3 Isoform

Author(s) -

Yajun Tang,

Xiangyang Liu,

Rebecca K. Zoltoski,

Layne A. Novak,

Raúl Herrera,

Isabelle Richard,

J.R. Kuszak,

Nalin M. Kumar

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-0926

Subject(s) - calpain , knockout mouse , gene isoform , cataracts , crystallin , gene knockout , in vivo , cleavage (geology) , biology , gene , microbiology and biotechnology , chemistry , endocrinology , genetics , biochemistry , paleontology , fracture (geology) , enzyme

Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 knockout mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research