Open AccessIdentification of Novel Dendritic Cell Populations in Normal Mouse Retina
Author(s) -
Heping Xu,
Rosemary Dawson,
John V. Forrester,
Janet Liversidge
Publication year - 2007
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.06-0697
Subject(s) - retina , mhc class ii , biology , major histocompatibility complex , pathology , inflammation , population , cd11c , retinal , retinal pigment epithelium , immunology , immune system , phenotype , medicine , genetics , neuroscience , biochemistry , environmental health , gene
Whether tissue resident or infiltrating antigen-presenting cells (APCs) are involved in modulating immune responses in the retina and initiating inflammation is controversial. In this histologic study, the authors examine the retinas of mice strains with different susceptibility to experimental autoimmune uveoretinitis (EAU) for tissue resident APC.