Cell Surface Glycoconjugate Abnormalities and Corneal Epithelial Wound Healing in thePax6+/−Mouse Model of Aniridia-Related Keratopathy | Zendy

Romana Kucerova | Zendy; Jingxing Ou | Zendy; Diane Lawson | Zendy; Lucy J. Leiper | Zendy; J. Martin Collinson | Zendy

Open Access

Cell Surface Glycoconjugate Abnormalities and Corneal Epithelial Wound Healing in thePax6^+/⁻Mouse Model of Aniridia-Related Keratopathy

Author(s) -

Romana Kucerova,

Jingxing Ou,

Diane Lawson,

Lucy J. Leiper,

J. Martin Collinson

Publication year - 2006

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-0581

Subject(s) - pax6 , aniridia , glycoconjugate , wound healing , corneal epithelium , biology , cornea , conjunctiva , pathology , microbiology and biotechnology , immunology , medicine , biochemistry , gene , neuroscience , transcription factor

Congenital aniridia due to heterozygosity for Pax6 is associated with ocular surface disease, including keratopathy. This study investigated how defects in glycoconjugate component of the cell surface of Pax6+/- could cause the abnormal cellular migration phenotypes associated with the disease.

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