Gene Transfer to Rabbit Retina with Electron Avalanche Transfection | Zendy

Thomas W. Chalberg | Zendy; Alexander Vankov | Zendy; Fanni Molnár | Zendy; Alexander F. Butterwick | Zendy; Philip Huie | Zendy; Michèle P. Calos | Zendy; Daniel Palanker | Zendy

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Gene Transfer to Rabbit Retina with Electron Avalanche Transfection

Author(s) -

Thomas W. Chalberg,

Alexander Vankov,

Fanni Molnár,

Alexander F. Butterwick,

Philip Huie,

Michèle P. Calos,

Daniel Palanker

Publication year - 2006

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-0092

Subject(s) - electroporation , transfection , retina , chorioallantoic membrane , microbiology and biotechnology , gene delivery , biophysics , in vivo , biology , chemistry , gene , biochemistry , genetics , neuroscience

Nonviral gene therapy represents a promising treatment for retinal diseases, given clinically acceptable methods for efficient gene transfer. Electroporation is widely used for transfection, but causes significant collateral damage and a high rate of cell death, especially in applications in situ. This study was conducted in the interest of developing efficient and less toxic forms of gene transfer for the eye.

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