Transport of Truncated Rhodopsin and Its Effects on Rod Function and Degeneration | Zendy

Edwin S. Lee | Zendy; John G. Flannery | Zendy

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Transport of Truncated Rhodopsin and Its Effects on Rod Function and Degeneration

Author(s) -

Edwin S. Lee,

John G. Flannery

Publication year - 2007

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.06-0035

Subject(s) - rhodopsin , retinal degeneration , biology , retinal , microbiology and biotechnology , chemistry , biochemistry

Most transgenic animal models of retinal degeneration caused by rhodopsin mutations express the rhodopsin transgene on a wild-type (WT) genetic background. Previous studies have demonstrated that one mechanism of retinal degeneration is rhodopsin overexpression. To study the effect of C-terminal truncation of rhodopsin without the confounding factors of overexpression, several lines of transgenic mice were generated that expressed a C-terminal rhodopsin mutation on rhodopsin-knockout backgrounds.

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