Immunohistochemical Evidence of a Melanopsin Cone in Human Retina | Zendy

Ouria DkhissiBenyahya | Zendy; Camille Rieux | Zendy; Roelof A. Hut | Zendy; Howard M. Cooper | Zendy

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Immunohistochemical Evidence of a Melanopsin Cone in Human Retina

Author(s) -

Ouria DkhissiBenyahya,

Camille Rieux,

Roelof A. Hut,

Howard M. Cooper

Publication year - 2006

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.05-1459

Subject(s) - melanopsin , photopigment , intrinsically photosensitive retinal ganglion cells , retina , opsin , biology , neuroscience , visual phototransduction , giant retinal ganglion cells , ganglion , anatomy , pupillary light reflex , microbiology and biotechnology , retinal , rhodopsin , retinal ganglion cell , pupil , biochemistry

Melanopsin, expressed in a subset of intrinsically photosensitive ganglion cells that project to the suprachiasmatic nucleus (SCN), is involved in the photic entrainment of circadian rhythms and other non-image-forming functions (pupil light reflex, masking, acute heart rate response, and alertness). Melanopsin has recently been shown to be a "bireactive" photopigment that functions as a photosensory opsin using 11-cis retinaldehyde as a chromophore and has intrinsic photoisomerase activity. Melanopsin is widely distributed in the retina of vertebrates and, depending on the species, is expressed in ganglion, amacrine, horizontal, and photoreceptor cells. The present study was conducted to determine the distribution of this opsin in the human retina.

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