Open AccessDetection of thebcl-2t(14;18) Translocation and Proto-Oncogene Expression in Primary Intraocular Lymphoma
Author(s) -
Dana Wallace,
Defen Shen,
George F. Reed,
Masaru Miyanaga,
Manabu Mochizuki,
H. Nida Sen,
Samuel S. Dahr,
Ronald Buggage,
Robert B. Nussenblatt,
Chi–Chao Chan
Publication year - 2006
Publication title -
investigative ophthalmology and visual science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.935
H-Index - 218
eISSN - 1552-5783
pISSN - 0146-0404
DOI - 10.1167/iovs.05-1312
Subject(s) - chromosomal translocation , intraocular lymphoma , lymphoma , biology , gene , pathology , microdissection , microbiology and biotechnology , medicine , immunology , genetics
Primary intraocular lymphoma (PIOL) is a diffuse large B cell lymphoma that initially infiltrates the retina, vitreous, or optic nerve head, with or without central nervous system involvement. This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells.