Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo | Zendy

Li Guo | Zendy; T.E. Salt | Zendy; Annelie Maaß | Zendy; Vy Luong | Zendy; Stephen E. Moss | Zendy; Fred W. Fitzke | Zendy; M. Francesca Cordeiro | Zendy

Open Access

Assessment of Neuroprotective Effects of Glutamate Modulation on Glaucoma-Related Retinal Ganglion Cell Apoptosis In Vivo

Author(s) -

Li Guo,

T.E. Salt,

Annelie Maaß,

Vy Luong,

Stephen E. Moss,

Fred W. Fitzke,

M. Francesca Cordeiro

Publication year - 2006

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.05-0754

Subject(s) - neuroprotection , retinal ganglion cell , pharmacology , nmda receptor , glutamate receptor , metabotropic glutamate receptor , in vivo , retinal , medicine , biology , receptor , ophthalmology , microbiology and biotechnology

To assess the neuroprotective effects of different glutamate modulation strategies, with a nonselective (MK801) and a selective (ifenprodil) NMDA receptor antagonist and a metabotropic glutamate receptor agonist (mGluR Group II, LY354740), in glaucoma-related in vivo rat models of retinal ganglion cell (RGC) apoptosis.

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