A Critical Role of CaBP4 in the Cone Synapse | Zendy

Tadao Maeda | Zendy; Janis Lem | Zendy; Krzysztof Palczewski | Zendy; Franc ̧oise Haeseleer | Zendy

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A Critical Role of CaBP4 in the Cone Synapse

Author(s) -

Tadao Maeda,

Janis Lem,

Krzysztof Palczewski,

Franc ̧oise Haeseleer

Publication year - 2005

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.05-0478

Subject(s) - electroretinography , outer plexiform layer , knockout mouse , retina , synapse , transducin , retinal , erg , biology , visual phototransduction , immunocytochemistry , microbiology and biotechnology , scotopic vision , biophysics , neuroscience , anatomy , endocrinology , receptor , biochemistry , rhodopsin

CaBP4, a photoreceptor-specific protein of the rods and cones, is essential for the development and maintenance of the mouse photoreceptor synapse. In this study, double CaBP4/rod alpha-transducin knockout (Cabp4(-/-)Gnat1(-/-)) mice lacking the rod-mediated component of electrophysiologic responses were generated and analyzed to investigate the role of CaBP4 in cones.

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