Efficacy and Selectivity of Phosphodiesterase-Targeted Drugs in Inhibiting Photoreceptor Phosphodiesterase (PDE6) in Retinal Photoreceptors | Zendy

Xiujun Zhang | Zendy; Qing Feng | Zendy; Rick Cote | Zendy

Open Access

Efficacy and Selectivity of Phosphodiesterase-Targeted Drugs in Inhibiting Photoreceptor Phosphodiesterase (PDE6) in Retinal Photoreceptors

Author(s) -

Xiujun Zhang,

Qing Feng,

Rick Cote

Publication year - 2005

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.05-0257

Subject(s) - zaprinast , phosphodiesterase , vardenafil , protein subunit , enzyme , potency , cgmp specific phosphodiesterase type 5 , chemistry , rolipram , biochemistry , pharmacology , sildenafil , biology , in vitro , tadalafil , anatomy , gene

Phosphodiesterase (PDE) inhibitors are important therapeutic agents, but their effects on photoreceptor PDE (PDE6) and photoreceptor cells are poorly understood. The potency and selectivity of various classes of PDE inhibitors on purified rod and cone PDE6 and on intact rod outer segments (ROS) were characterized.

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