Intravitreal Injection of Corticosteroid Attenuates Leukostasis and Vascular Leakage in Experimental Diabetic Retina | Zendy

Hiroshi Tamura | Zendy; Kazuaki Miyamoto | Zendy; Junichi Kiryu | Zendy; Shinsuke Miyahara | Zendy; Hideto Katsuta | Zendy; Fumitaka Hirose | Zendy; Kunihiro Musashi | Zendy; Nagahisa Yoshimura | Zendy

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Intravitreal Injection of Corticosteroid Attenuates Leukostasis and Vascular Leakage in Experimental Diabetic Retina

Author(s) -

Hiroshi Tamura,

Kazuaki Miyamoto,

Junichi Kiryu,

Shinsuke Miyahara,

Hideto Katsuta,

Fumitaka Hirose,

Kunihiro Musashi,

Nagahisa Yoshimura

Publication year - 2005

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.04-0905

Subject(s) - leukostasis , dexamethasone , medicine , diabetes mellitus , retinal , retina , blood–retinal barrier , intraperitoneal injection , diabetic retinopathy , streptozotocin , in vivo , vascular permeability , evans blue , corticosteroid , endocrinology , pharmacology , ophthalmology , biology , microbiology and biotechnology , neuroscience

Recently, intravitreal injection of corticosteroids has been in wide use as a treatment for diabetic macular edema, and the outcomes have been favorable. However, the exact mechanism remains unclear. The hypothesis for the current study was that intravitreal corticosteroids may improve diabetic retinal edema by amelioration of blood-retinal barrier (BRB) breakdown, by inhibiting leukocyte stasis (leukostasis).

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