Roles of Thrombospondin-1 and -2 in Regulating Corneal and Iris Angiogenesis | Zendy

Claus Cursiefen | Zendy; Sharmila Masli | Zendy; Tat Fong Ng | Zendy; M. Reza Dana | Zendy; Paul Börnstein | Zendy; Jack Lawler | Zendy; J. Wayne Streilein | Zendy

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Roles of Thrombospondin-1 and -2 in Regulating Corneal and Iris Angiogenesis

Author(s) -

Claus Cursiefen,

Sharmila Masli,

Tat Fong Ng,

M. Reza Dana,

Paul Börnstein,

Jack Lawler,

J. Wayne Streilein

Publication year - 2004

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.03-0940

Subject(s) - angiogenesis , cd31 , neovascularization , cornea , thrombospondin 1 , corneal neovascularization , thrombospondin , iris (biosensor) , biology , stroma , western blot , pathology , immunohistochemistry , immunology , medicine , ophthalmology , cancer research , matrix metalloproteinase , genetics , computer security , metalloproteinase , computer science , gene , biometrics

Thrombospondin (TSP)-1 and -2 are important antiangiogenic factors thought to be involved in maintaining corneal avascularity (angiogenic privilege). This study was undertaken to investigate whether deficiencies of these factors altered developmental and inflammation-induced angiogenesis in the cornea and developmental angiogenesis of the iris of mice.

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