Ex Vivo Adenovirus-Mediated Gene Transfer to Corneal Graft Endothelial Cells in Mice | Zendy

Ying Qian | Zendy; FeeLai Leong | Zendy; Andrius Kazlauskas | Zendy; M. Reza Dana | Zendy

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Ex Vivo Adenovirus-Mediated Gene Transfer to Corneal Graft Endothelial Cells in Mice

Author(s) -

Ying Qian,

FeeLai Leong,

Andrius Kazlauskas,

M. Reza Dana

Publication year - 2004

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.03-0901

Subject(s) - ex vivo , green fluorescent protein , corneal endothelium , alloimmunity , in vivo , corneal transplantation , transplantation , cornea , microbiology and biotechnology , corneal transplant , endothelium , corneal epithelium , viral vector , biology , genetic enhancement , pathology , medicine , gene , recombinant dna , surgery , biochemistry , neuroscience , endocrinology

Genetic modulation of donor tissue before corneal transplantation may have the potential to modulate alloimmunity and/or to prevent corneal endothelial cell death. This study was conducted to optimize adenovirus-mediated gene transfer to donor corneal endothelium and to delineate the kinetics of marker gene expression in syngeneic and allogeneic corneal grafts.

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