The Effects of Phenylephrine on Pupil Diameter and Accommodation in Rhesus Monkeys | Zendy

Lisa A. Ostrin | Zendy; Adrian Glasser | Zendy

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The Effects of Phenylephrine on Pupil Diameter and Accommodation in Rhesus Monkeys

Author(s) -

Lisa A. Ostrin,

Adrian Glasser

Publication year - 2003

Publication title -

investigative ophthalmology and visual science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.935

H-Index - 218

eISSN - 1552-5783

pISSN - 0146-0404

DOI - 10.1167/iovs.03-0704

Subject(s) - phenylephrine , mydriasis , medicine , ciliary muscle , stimulation , pupil , pupillary response , ophthalmology , iris (biosensor) , anesthesia , accommodation , psychology , blood pressure , neuroscience , computer security , biometrics , computer science

Phenylephrine is used to dilate the iris through alpha-adrenergic stimulation of the iris dilator muscle. Sympathetic stimulation of the ciliary muscle is believed to be inhibitory, decreasing accommodative amplitude. Investigations in humans have suggested some loss of functional accommodation after phenylephrine. It is unclear whether this loss is due to direct action of phenylephrine on the ciliary muscle or to secondary optical factors associated with mydriasis. The purpose of this study was to determine whether phenylephrine affects Edinger-Westphal (EW)-stimulated accommodation in rhesus monkeys.

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