Characterization of Synthesized NANO−encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT | Zendy

Qingwen Ni | Zendy; Hong Dixon | Zendy; Gloria E. Gutierrez | Zendy; Long Bi | Zendy; YiXian Qin | Zendy

Open Access

Characterization of Synthesized NANO−encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT

Author(s) -

Qingwen Ni,

Hong Dixon,

Gloria E. Gutierrez,

Long Bi,

YiXian Qin

Publication year - 2013

Publication title -

advances in bioscience and bioengineering

Language(s) - English

Resource type - Journals

eISSN - 2330-4162

pISSN - 2330-4154

DOI - 10.11648/j.abb.20130101.11

Subject(s) - drug delivery , biomedical engineering , materials science , nano , magnetic resonance imaging , drug , chemistry , nanotechnology , medicine , pharmacology , radiology , composite material

A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model.

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