Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study | Zendy

Rob Molenberg | Zendy; Chris H. L. Thio | Zendy; Marlien W. Aalbers | Zendy; Maarten Uyttenboogaart | Zendy; Susanna C. Larsson | Zendy; Mark K. Bakker | Zendy; Ynte M. Ruigrok | Zendy; Harold Snieder | Zendy; J. Marc C. van Dijk | Zendy

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Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study

Author(s) -

Rob Molenberg,

Chris H. L. Thio,

Marlien W. Aalbers,

Maarten Uyttenboogaart,

Susanna C. Larsson,

Mark K. Bakker,

Ynte M. Ruigrok,

Harold Snieder,

J. Marc C. van Dijk

Publication year - 2022

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.121.038035

Subject(s) - medicine , mendelian randomization , subarachnoid hemorrhage , stroke (engine) , hormone , randomization , clinical trial , gene , genetic variants , genetics , genotype , biology , mechanical engineering , engineering

The risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased in postmenopausal women compared with men of similar age, suggesting a role for sex hormones. We aimed to explore whether sex hormones, and age at menarche/menopause have a causal effect on aSAH risk by conducting a 2-sample MR study (Mendelian randomization).

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