Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial | Zendy

Iris Lettow | Zendy; Märit Jensen | Zendy; Eckhard Schlemm | Zendy; Florent Boutitie | Zendy; Fanny Quandt | Zendy; Bastian Cheng | Zendy; Martin Ebinger | Zendy; Matthias Endres | Zendy; Jochen B. Fiebach | Zendy; Vincent Thijs | Zendy; Robin Lemmens | Zendy; Keith W. Muir | Zendy; Norbert Nighoghossian | Zendy; Salvador Pedraza | Zendy; Claus Z. Simonsen | Zendy; Christian Gerloff | Zendy; Götz Thomalla | Zendy

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Serious Adverse Events and Their Impact on Functional Outcome in Acute Ischemic Stroke in the WAKE-UP Trial

Author(s) -

Iris Lettow,

Märit Jensen,

Eckhard Schlemm,

Florent Boutitie,

Fanny Quandt,

Bastian Cheng,

Martin Ebinger,

Matthias Endres,

Jochen B. Fiebach,

Vincent Thijs,

Robin Lemmens,

Keith W. Muir,

Norbert Nighoghossian,

Salvador Pedraza,

Claus Z. Simonsen,

Christian Gerloff,

Götz Thomalla

Publication year - 2021

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.033425

Subject(s) - medicine , modified rankin scale , thrombolysis , stroke (engine) , randomized controlled trial , odds ratio , adverse effect , clinical trial , myocardial infarction , ischemic stroke , ischemia , mechanical engineering , engineering

During the first days and weeks after an acute ischemic stroke, patients are prone to complications that can influence further treatment, recovery, and functional outcome. In clinical trials, severe complications are recorded as serious adverse events (SAE). We analyzed the effect of SAE on functional outcome and predictors of SAE in the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke).

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