Genetics of Intracranial Aneurysms | Zendy

Mark K. Bakker | Zendy; Ynte M. Ruigrok | Zendy

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Genetics of Intracranial Aneurysms

Author(s) -

Mark K. Bakker,

Ynte M. Ruigrok

Publication year - 2021

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.032621

Subject(s) - medicine , subarachnoid hemorrhage , aneurysm , disease , genome wide association study , stroke (engine) , genetic variation , genetic association , genetic variants , bioinformatics , intensive care medicine , genotype , surgery , genetics , single nucleotide polymorphism , gene , mechanical engineering , population , environmental health , biology , engineering

Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number of known genetic risk factors and improved our understanding of the disease. In this review, we provide an overview of the current status of the field and highlight the latest findings of family based, sequencing, and genome-wide association studies. We further describe opportunities of genetic analyses for understanding, prevention, and treatment of the disease.

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