Clinical Outcomes and Identification of Patients With Persistent Penumbral Profiles Beyond 24 Hours From Last Known Well | Zendy

Amrou Sarraj | Zendy; Michael Mlynash | Zendy; Jeremy J. Heit | Zendy; Deep Pujara | Zendy; Maarten G. Lansberg | Zendy; Michael P. Marks | Zendy; Gregory W. Albers | Zendy

Open Access

Clinical Outcomes and Identification of Patients With Persistent Penumbral Profiles Beyond 24 Hours From Last Known Well

Author(s) -

Amrou Sarraj,

Michael Mlynash,

Jeremy J. Heit,

Deep Pujara,

Maarten G. Lansberg,

Michael P. Marks,

Gregory W. Albers

Publication year - 2021

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.031147

Subject(s) - medicine , penumbra , interquartile range , modified rankin scale , perfusion , nuclear medicine , randomization , magnetic resonance imaging , radiology , clinical trial , cardiology , ischemic stroke , ischemia

DEFUSE 3 (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3) infarct volumes at 24 hours did not significantly differ in the endovascular thrombectomy (EVT) versus medical management (MM) only groups. We hypothesized that this was due to underestimation of the final infarct volume among patients with persistent penumbral tissue 24 hours after randomization that subsequently progressed to infarction. We sought to assess the clinical outcomes in patients with persistent penumbral profile >24 hours from last known well and identify them based on the Persistent Penumbra Index (PPI, time-to-maximum of the residue function >6 s perfusion lesion divided by diffusion-weighted magnetic resonance imaging lesion volume on 24-hour postrandomization imaging).

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