Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease | Zendy

Iolanda Lázaro | Zendy; Montserrat Cofán | Zendy; Antonio J. Amor | Zendy; Emilio Ortega | Zendy; Tania-Marisa Freitas-Simoes | Zendy; Laura Llull | Zendy; Sergio Amaro | Zendy; Gaspar Mestres | Zendy; Xavier Yugueros | Zendy; William S. Harris | Zendy; Vicente Riambau | Zendy; Aleix SalaVila | Zendy

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Linoleic Acid Status in Cell Membranes Inversely Relates to the Prevalence of Symptomatic Carotid Artery Disease

Author(s) -

Iolanda Lázaro,

Montserrat Cofán,

Antonio J. Amor,

Emilio Ortega,

Tania-Marisa Freitas-Simoes,

Laura Llull,

Sergio Amaro,

Gaspar Mestres,

Xavier Yugueros,

William S. Harris,

Vicente Riambau,

Aleix SalaVila

Publication year - 2020

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.030477

Subject(s) - medicine , docosahexaenoic acid , carotid endarterectomy , eicosapentaenoic acid , linoleic acid , carotid artery disease , stroke (engine) , odds ratio , asymptomatic , red blood cell , gastroenterology , disease , fatty acid , cardiology , polyunsaturated fatty acid , carotid arteries , biochemistry , biology , mechanical engineering , engineering

Background and Purpose: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease. Methods: We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography. Results: In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022–0.607],P =0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids.Conclusions: Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.

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