Rivaroxaban for Prevention of Covert Brain Infarcts and Cognitive Decline | Zendy

Mukul Sharma | Zendy; Robert G. Hart | Zendy; Eric E. Smith | Zendy; Jackie Bosch | Zendy; John W. Eikelboom | Zendy; Stuart J. Connolly | Zendy; Leanne Dyal | Zendy; K. Reeh | Zendy; Amparo Casanova | Zendy; Rafael Díaz | Zendy; Patricio LópezJaramillo | Zendy; Georg Ertl | Zendy; Stefan Störk | Zendy; Gilles R. Dagenais | Zendy; Eva Lonn | Zendy; Lars Rydén | Zendy; Andrew Tonkin | Zendy; George Varigos | Zendy; Deepak L. Bhatt | Zendy; Kelley R. Branch | Zendy; Jeffrey L. Probstfield | Zendy; JaeHyung Kim | Zendy; Martin O’Donnell | Zendy; Dragoş Vinereanu | Zendy; Keith A.A. Fox | Zendy; Yan Liang | Zendy; Lisheng Liu | Zendy; Jun Zhu | Zendy; Nana Pogosova | Zendy; Aldo P. Maggioni | Zendy; Álvaro Avezum | Zendy; Leopoldo Soares Piegas | Zendy; Katalin Keltai | Zendy; Matyàs Keltai | Zendy; Scott D. Berkowitz | Zendy; Salim Yusuf | Zendy

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Rivaroxaban for Prevention of Covert Brain Infarcts and Cognitive Decline

Author(s) -

Mukul Sharma,

Robert G. Hart,

Eric E. Smith,

Jackie Bosch,

John W. Eikelboom,

Stuart J. Connolly,

Leanne Dyal,

K. Reeh,

Amparo Casanova,

Rafael Díaz,

Patricio LópezJaramillo,

Georg Ertl,

Stefan Störk,

Gilles R. Dagenais,

Eva Lonn,

Lars Rydén,

Andrew Tonkin,

George Varigos,

Deepak L. Bhatt,

Kelley R. Branch,

Jeffrey L. Probstfield,

JaeHyung Kim,

Martin O’Donnell,

Dragoş Vinereanu,

Keith A.A. Fox,

Yan Liang,

Lisheng Liu,

Jun Zhu,

Nana Pogosova,

Aldo P. Maggioni,

Álvaro Avezum,

Leopoldo Soares Piegas,

Katalin Keltai,

Matyàs Keltai,

Scott D. Berkowitz,

Salim Yusuf

Publication year - 2020

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.029762

Subject(s) - medicine , aspirin , rivaroxaban , stroke (engine) , hyperintensity , cardiology , magnetic resonance imaging , white matter , infarction , anesthesia , myocardial infarction , radiology , warfarin , atrial fibrillation , mechanical engineering , engineering

Covert brain infarcts are associated with cognitive decline. It is not known whether therapies that prevent symptomatic stroke prevent covert infarcts. COMPASS compared rivaroxaban with and without aspirin with aspirin for the prevention of stroke, myocardial infarction, and vascular death in participants with stable vascular disease and was terminated early because of benefits of rivaroxaban 2.5 mg twice daily plus aspirin over aspirin. We obtained serial magnetic resonance imagings and cognitive tests in a consenting subgroup of COMPASS patients to examine treatment effects on infarcts, cerebral microbleeds, and white matter hyperintensities.

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