Cilostazol for Secondary Prevention of Stroke and Cognitive Decline
Author(s) -
Caroline McHutchison,
Gordon W. Blair,
Jason P. Appleton,
Francesca M. Chappell,
Fergus Doubal,
Philip M. Bath,
Joanna M. Wardlaw
Publication year - 2020
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.120.029454
Subject(s) - medicine , cilostazol , stroke (engine) , aspirin , adverse effect , randomized controlled trial , odds ratio , placebo , clopidogrel , pathology , mechanical engineering , alternative medicine , engineering
Cilostazol, a phosphodiesterase 3' inhibitor, is used in Asia-Pacific countries for stroke prevention, but rarely used elsewhere. In addition to weak antiplatelet effects, it stabilizes endothelium, aids myelin repair and astrocyte-neuron energy transfer in laboratory models, effects that may be beneficial in preventing small vessel disease progression.
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