Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery | Zendy

Bharath Chelluboina | Zendy; TaeHee Kim | Zendy; Suresh L. Mehta | Zendy; Jooyong Kim | Zendy; Saivenkateshkomal Bathula | Zendy; Raghu Vemuganti | Zendy

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Impact of Age and Sex on α-Syn (α-Synuclein) Knockdown-Mediated Poststroke Recovery

Author(s) -

Bharath Chelluboina,

TaeHee Kim,

Suresh L. Mehta,

Jooyong Kim,

Saivenkateshkomal Bathula,

Raghu Vemuganti

Publication year - 2020

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.120.028978

Subject(s) - gene knockdown , medicine , stroke (engine) , brain damage , neuroprotection , ischemia , stroke recovery , middle cerebral artery , small interfering rna , anesthesia , cardiology , rna , physical therapy , rehabilitation , apoptosis , biology , gene , mechanical engineering , biochemistry , engineering

Background and Purpose: Increased expression of α-Syn (α-Synuclein) is known to mediate secondary brain damage after stroke. We presently studied if α-Syn knockdown can protect ischemic brain irrespective of sex and age. Methods: Adult and aged male and female mice were subjected to transient middle cerebral artery occlusion. α-Syn small interfering RNA (siRNA) was administered intravenous at 30 minutes or 3 hour reperfusion. Poststroke motor deficits were evaluated between day 1 and 7 and infarct volume was measured at day 7 of reperfusion. Results: α-Syn knockdown significantly decreased poststroke brain damage and improved poststroke motor function recovery in adult and aged mice of both sexes. However, the window of therapeutic opportunity for α-Syn siRNA is very limited. Conclusions: α-Syn plays a critical role in ischemic brain damage and preventing α-Syn protein expression early after stroke minimizes poststroke brain damage leading to better functional outcomes irrespective of age and sex.

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