Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke | Zendy

Boris Modrau | Zendy; Grethe Andersen | Zendy; Irene Klærke Mikkelsen | Zendy; Anne Højager Nielsen | Zendy; Mikkel Bo Hansen | Zendy; Martin Berg Johansen | Zendy; Helle Wulf Eskildsen | Zendy; Jan Plougmann Povlsen | Zendy; Yousef Yavarian | Zendy; Kim Mouridsen | Zendy; Leif Østergaard | Zendy; Flemming W. Bach | Zendy; Niels Hjort | Zendy

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Theophylline as an Add-On to Thrombolytic Therapy in Acute Ischemic Stroke

Author(s) -

Boris Modrau,

Grethe Andersen,

Irene Klærke Mikkelsen,

Anne Højager Nielsen,

Mikkel Bo Hansen,

Martin Berg Johansen,

Helle Wulf Eskildsen,

Jan Plougmann Povlsen,

Yousef Yavarian,

Kim Mouridsen,

Leif Østergaard,

Flemming W. Bach,

Niels Hjort

Publication year - 2020

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.119.027446

Subject(s) - medicine , stroke (engine) , theophylline , ischemic stroke , acute stroke , cardiology , intensive care medicine , ischemia , tissue plasminogen activator , mechanical engineering , engineering

Delayed recanalization increases the risk of infarct growth and poor clinical outcome in acute ischemic stroke. The vasoactive agent theophylline has shown neuroprotective effects in animal stroke models but inconclusive results in case series and randomized clinical trials. The primary objective of this study was to evaluate whether theophylline, as an add-on to thrombolytic therapy, is safe and effective in acute ischemic stroke patients.

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