Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke | Zendy

Nuria P. TorresAguila | Zendy; Caty Carrera | Zendy; Anne-Katrine Giese | Zendy; Natàlia Cullell | Zendy; Elena Muiño | Zendy; Jara CárcelMárquez | Zendy; Cristina Gallego-Fábrega | Zendy; Jonathan González-Sanchez | Zendy; María del Mar Freijo | Zendy; José ÁlvarezSabín | Zendy; Carlos A. Molina | Zendy; Marc Ribó | Zendy; Jordi JiménezConde | Zendy; Jaume Roquer | Zendy; Tomás Sobrino | Zendy; Francisco Campos | Zendy; José Castillo | Zendy; Lucía Muñoz-Narbona | Zendy; Elena LópezCancio | Zendy; Antoni Dávalos | Zendy; Rosa Díaz-Navarro | Zendy; Sílvia Tur | Zendy; Cristòfol Vives-Bauzà | Zendy; Gemma SerranoHeras | Zendy; Tomás Segura | Zendy; Jerzy Krupiński | Zendy; Raquel DelgadoMederos | Zendy; Joan MartíFàbregas | Zendy; Laura Heitsch | Zendy; Laura Ibáñez | Zendy; Carlos Cruchaga | Zendy; Natalia S. Rost | Zendy; Joan Montaner | Zendy; JinMoo Lee | Zendy; Israel FernándezCadenas | Zendy

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Genome-Wide Association Study of White Blood Cell Counts in Patients With Ischemic Stroke

Author(s) -

Nuria P. TorresAguila,

Caty Carrera,

Anne-Katrine Giese,

Natàlia Cullell,

Elena Muiño,

Jara CárcelMárquez,

Cristina Gallego-Fábrega,

Jonathan González-Sanchez,

María del Mar Freijo,

José ÁlvarezSabín,

Carlos A. Molina,

Marc Ribó,

Jordi JiménezConde,

Jaume Roquer,

Tomás Sobrino,

Francisco Campos,

José Castillo,

Lucía Muñoz-Narbona,

Elena LópezCancio,

Antoni Dávalos,

Rosa Díaz-Navarro,

Sílvia Tur,

Cristòfol Vives-Bauzà,

Gemma SerranoHeras,

Tomás Segura,

Jerzy Krupiński,

Raquel DelgadoMederos,

Joan MartíFàbregas,

Laura Heitsch,

Laura Ibáñez,

Carlos Cruchaga,

Natalia S. Rost,

Joan Montaner,

JinMoo Lee,

Israel FernándezCadenas

Publication year - 2019

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.119.026593

Subject(s) - medicine , genome wide association study , stroke (engine) , immune system , locus (genetics) , genetic association , population , ischemic stroke , immunology , gene , oncology , bioinformatics , genotype , genetics , single nucleotide polymorphism , ischemia , biology , environmental health , engineering , mechanical engineering

Background and Purpose— Immune cells play a key role in the first 24h poststroke (acute phase), being associated with stroke outcome. We aimed to find genetic risk factors associated with leukocyte counts during the acute phase of stroke. Methods— Ischemic stroke patients with leukocyte counts data during the first 24h were included. Genome-wide association study and gene expression studies were performed. Results— Our genome-wide association study, which included 2064 (Discovery) and 407 (Replication) patients, revealed a new locus (14q24.3) associated with leukocyte counts. After Joint analysis (n=2471) 5 more polymorphisms reached genome-wide significance (P <5×10−8 ). The 14q24.3 locus was associated with acute stroke outcome (rs112809786,P =0.036) and withACOT1 andPTGR2 gene expression. Previous polymorphisms associated with leukocyte counts in general-population did not show any significance in our study.Conclusions— We have found the first locus associated with leukocyte counts in ischemic stroke, also associated with acute outcome. Genetic analysis of acute endophenotypes could be useful to find the genetic factors associated with stroke outcome. Our findings suggested a different modulation of immune cells in stroke compared with healthy conditions.

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