Copeptin Kinetics in Acute Ischemic Stroke May Differ According to Revascularization Strategies

Background and Purpose— Prognostic value of copeptin in acute ischemic stroke has been widely reported. This study aimed to evaluate copeptin temporal profile according to revascularization strategies and the development of brain edema and hemorrhagic transformation. Methods— Plasma copeptin and brain edema and hemorrhagic transformation assessed by computed tomography/magnetic resonance imaging were evaluated upon admission (T0 ), at 24 hours (T1 ), and between the third and fifth day of hospitalization (T2 ) in 34 acute ischemic stroke patients.Results— Median copeptin concentration was 50.71 pmol/L atT0 , 18.31 pmol/L atT1 , and 10.92 pmol/L atT2 . Copeptin atT1 was higher in patients with medium/severe brain edema atT2 (32.25 versus 13.67 pmol/L;P =0.038) and hemorrhagic transformation atT1 (93.10 versus 13.67 pmol/L;P <0.003) andT2 (85.70 versus 14.45 pmol/L;P =0.024). Copeptin level drop (CopΔT1−T0 ) was significantly steeper in patients receiving revascularization, particularly in those undergoing combined therapy (−129.34 versus −5.43 pmol/L;P =0.038). ΔT1−T0 also correlated with Thrombolysis in Cerebral Infarction score (P <0.001).Conclusions— Copeptin resulted associated with brain edema and hemorrhagic transformation in acute ischemic stroke, and its drop at 24 hours may mirror effective brain vessel recanalization.