SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke) | Zendy

Craig J. Smith | Zendy; Sharon Hulme | Zendy; Andy Vail | Zendy; Calvin Heal | Zendy; Adrian ParryJones | Zendy; Sylvia Scarth | Zendy; Karen Hopkins | Zendy; Margaret E. Hoadley | Zendy; Stuart M. Allan | Zendy; Nancy J. Rothwell | Zendy; Stephen J. Hopkins | Zendy; Pippa Tyrrell | Zendy

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SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

Author(s) -

Craig J. Smith,

Sharon Hulme,

Andy Vail,

Calvin Heal,

Adrian ParryJones,

Sylvia Scarth,

Karen Hopkins,

Margaret E. Hoadley,

Stuart M. Allan,

Nancy J. Rothwell,

Stephen J. Hopkins,

Pippa Tyrrell

Publication year - 2018

Publication title -

stroke

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.118.020750

Subject(s) - medicine , modified rankin scale , interleukin 1 receptor antagonist , stroke (engine) , thrombolysis , odds ratio , receptor antagonist , placebo , interleukin , confidence interval , antagonist , cytokine , ischemia , ischemic stroke , receptor , myocardial infarction , pathology , mechanical engineering , alternative medicine , engineering

The proinflammatory cytokine IL-1 (interleukin-1) has a deleterious role in cerebral ischemia, which is attenuated by IL-1 receptor antagonist (IL-1Ra). IL-1 induces peripheral inflammatory mediators, such as interleukin-6, which are associated with worse prognosis after ischemic stroke. We investigated whether subcutaneous IL-1Ra reduces the peripheral inflammatory response in acute ischemic stroke.

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