Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial | Zendy

Ka Sing Wong | Zendy; Pierre Amarenco | Zendy; Gregory W. Albers | Zendy; Hans Denison | Zendy; J. Donald Easton | Zendy; Scott Evans | Zendy; Peter Held | Zendy; Anders Himmelmänn | Zendy; Scott E. Kasner | Zendy; Mikael Knutsson | Zendy; Per Ladenvall | Zendy; Kazuo Minematsu | Zendy; Carlos A. Molina | Zendy; Yongjun Wang | Zendy; S. Claiborne Johnston | Zendy

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Efficacy and Safety of Ticagrelor in Relation to Aspirin Use Within the Week Before Randomization in the SOCRATES Trial

Author(s) -

Ka Sing Wong,

Pierre Amarenco,

Gregory W. Albers,

Hans Denison,

J. Donald Easton,

Scott Evans,

Peter Held,

Anders Himmelmänn,

Scott E. Kasner,

Mikael Knutsson,

Per Ladenvall,

Kazuo Minematsu,

Carlos A. Molina,

Yongjun Wang,

S. Claiborne Johnston

Publication year - 2018

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.118.020553

Subject(s) - ticagrelor , medicine , aspirin , stroke (engine) , myocardial infarction , hazard ratio , randomization , clinical endpoint , cardiology , randomized controlled trial , confidence interval , anesthesia , clopidogrel , mechanical engineering , engineering

SOCRATES (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), comparing ticagrelor with aspirin in patients with acute cerebral ischemia, found a nonsignificant 11% relative risk reduction for stroke, myocardial infarction, or death ( P =0.07). Aspirin intake before randomization could enhance the effect of ticagrelor by conferring dual antiplatelet effect during a high-risk period for subsequent stroke. Therefore, we explored the efficacy and safety of ticagrelor versus aspirin in the patients who received any aspirin the week before randomization.

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