Inhibition of CD147 (Cluster of Differentiation 147) Ameliorates Acute Ischemic Stroke in Mice by Reducing Thromboinflammation | Zendy

Rong Jin | Zendy; Adam Y. Xiao | Zendy; Rui Chen | Zendy; D. Neil Granger | Zendy; Guohong Li | Zendy

Open Access

Inhibition of CD147 (Cluster of Differentiation 147) Ameliorates Acute Ischemic Stroke in Mice by Reducing Thromboinflammation

Author(s) -

Rong Jin,

Adam Y. Xiao,

Rui Chen,

D. Neil Granger,

Guohong Li

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.018839

Subject(s) - medicine , ischemia , stroke (engine) , middle cerebral artery , pathogenesis , neuroprotection , thrombus , blood–brain barrier , tissue plasminogen activator , inflammation , platelet , fibrin , pathology , immunology , central nervous system , mechanical engineering , engineering

Inflammation and thrombosis currently are recognized as critical contributors to the pathogenesis of ischemic stroke. CD147 (cluster of differentiation 147), also known as extracellular matrix metalloproteinase inducer, can function as a key mediator of inflammatory and immune responses. CD147 expression is increased in the brain after cerebral ischemia, but its role in the pathogenesis of ischemic stroke remains unknown. In this study, we show that CD147 acts as a key player in ischemic stroke by driving thrombotic and inflammatory responses.

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