Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment | Zendy

Yu Sun | Zendy; Jolly Lee | Zendy; Henry D. Huang | Zendy; Mary B. Wagner | Zendy; Clinton H. Joiner | Zendy; David R. Archer | Zendy; Chia-Yi Kuan | Zendy

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Sickle Mice Are Sensitive to Hypoxia/Ischemia-Induced Stroke but Respond to Tissue-Type Plasminogen Activator Treatment

Author(s) -

Yu Sun,

Jolly Lee,

Henry D. Huang,

Mary B. Wagner,

Clinton H. Joiner,

David R. Archer,

Chia-Yi Kuan

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.018334

Subject(s) - medicine , ischemia , hypoxia (environmental) , sickle cell anemia , plasminogen activator , stroke (engine) , tissue plasminogen activator , thrombosis , vascular disease , transcranial doppler , cerebral hypoxia , cardiology , anesthesia , disease , mechanical engineering , chemistry , organic chemistry , oxygen , engineering

The effects of lytic stroke therapy in patients with sickle cell anemia are unknown, although a recent study suggested that coexistent sickle cell anemia does not increase the risk of cerebral hemorrhage. This finding calls for systemic analysis of the effects of thrombolytic stroke therapy, first in humanized sickle mice, and then in patients. There is also a need for additional predictive markers of sickle cell anemia-associated vasculopathy.

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