Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A 2A R (Adenosine A2A Receptor) Signaling | Zendy

Xin-Chun Ye | Zendy; Jin-Xia Hu | Zendy; Lei Li | Zendy; Qiang Li | Zendy; FuLei Tang | Zendy; Sen Lin | Zendy; Dong Sun | Zendy; Xiang-Dong Sun | Zendy; Gui-Yun Cui | Zendy; Lin Mei | Zendy; WenCheng Xiong | Zendy

Open Access

Astrocytic Lrp4 (Low-Density Lipoprotein Receptor–Related Protein 4) Contributes to Ischemia-Induced Brain Injury by Regulating ATP Release and Adenosine-A _2A R (Adenosine A2A Receptor) Signaling

Author(s) -

Xin-Chun Ye,

Jin-Xia Hu,

Lei Li,

Qiang Li,

FuLei Tang,

Sen Lin,

Dong Sun,

Xiang-Dong Sun,

Gui-Yun Cui,

Lin Mei,

WenCheng Xiong

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.018115

Subject(s) - astrogliosis , adenosine , astrocyte , adenosine a2a receptor , glutamate receptor , glial fibrillary acidic protein , brain ischemia , purinergic signalling , ischemia , biology , endocrinology , neuroscience , medicine , adenosine receptor , pharmacology , microbiology and biotechnology , receptor , central nervous system , agonist , immunohistochemistry

Lrp4 (low-density lipoprotein receptor-related protein 4) is predominantly expressed in astrocytes, where it regulates glutamatergic neurotransmission by suppressing ATP release. Here, we investigated Lrp4's function in ischemia/stroke-induced brain injury response, which includes glutamate-induced neuronal death and reactive astrogliosis.

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