Cerebral Microbleeds in Murine Amyloid Angiopathy | Zendy

Marilena Marinescu | Zendy; Li Sun | Zendy; Marc Fatar | Zendy; Andreas Neubauer | Zendy; Lothar R. Schad | Zendy; Joanne van Ryn | Zendy; Lorenz Lehmann | Zendy; Roland Veltkamp | Zendy

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Cerebral Microbleeds in Murine Amyloid Angiopathy

Author(s) -

Marilena Marinescu,

Li Sun,

Marc Fatar,

Andreas Neubauer,

Lothar R. Schad,

Joanne van Ryn,

Lorenz Lehmann,

Roland Veltkamp

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.017994

Subject(s) - medicine , dabigatran , intracerebral hemorrhage , warfarin , cerebral amyloid angiopathy , antithrombotic , stroke (engine) , anesthesia , cardiology , atrial fibrillation , dementia , disease , mechanical engineering , subarachnoid hemorrhage , engineering

Cerebral microbleeds (CMBs) predispose patients to intracerebral hemorrhage. Preclinical models to examine the effects of antithrombotic treatments on the development of clinically overt intracerebral hemorrhage are needed. We examined the natural course of CMB development and the effects of long-term anticoagulation with warfarin or dabigatran on cerebral micro- and macrohemorrhage in mice overexpressing the APP23 (amyloid precursor protein).

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