Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection | Zendy

Lili Cui | Zendy; Franziska Nitzsche | Zendy; Evgeny Pryazhnikov | Zendy; Marina Tibeykina | Zendy; Laura Tolppanen | Zendy; Jussi Rytkönen | Zendy; Tuulia Huhtala | Zendy; Jingwei Mu | Zendy; Leonard Khiroug | Zendy; Johannes Boltze | Zendy; Jukka Jolkkonen | Zendy

Open Access

Integrin α4 Overexpression on Rat Mesenchymal Stem Cells Enhances Transmigration and Reduces Cerebral Embolism After Intracarotid Injection

Author(s) -

Lili Cui,

Franziska Nitzsche,

Evgeny Pryazhnikov,

Marina Tibeykina,

Laura Tolppanen,

Jussi Rytkönen,

Tuulia Huhtala,

Jingwei Mu,

Leonard Khiroug,

Johannes Boltze,

Jukka Jolkkonen

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.017809

Subject(s) - mesenchymal stem cell , medicine , homing (biology) , transplantation , in vivo , pathology , stroke (engine) , integrin , surgery , biology , mechanical engineering , ecology , microbiology and biotechnology , engineering , receptor

Very late antigen-4 (integrin α4β1)/vascular cell adhesion molecule-1 mediates leukocyte trafficking and transendothelial migration after stroke. Mesenchymal stem cells (MSCs) typically express integrin β1 but insufficient ITGA4 (integrin α4), which limits their homing after intravascular transplantation. We tested whether ITGA4 overexpression on MSCs increases cerebral homing after intracarotid transplantation and reduces MSC-borne cerebral embolism.

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