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See related articles, p 2341, p 2632 Translational failure from bench to bedside in medical research may be due, at least in part, to the suboptimal quality of experimental studies. For example, the factors such as lack of blinding and randomization in experimental studies may lead to an overestimation of treatment effects, contributes to irreproducibility of experimental data, and subsequently blocks translation into the clinic.1 To overcome this dilemma, the Animal Research Reporting In vivo Experiments guidelines provided recommendations for design and reporting of animal experimental studies.2 Stroke was a pioneer in the effort to improve the quality of preclinical research by establishing a requirement for the reporting of methodological quality of animal studies by implementation of the Basic Science Checklist , a prerequisite for experimental research later delineated by the landmark article of Landis et al.3In a recent article, Ramirez et al4 systematically examined the …

High Appraisal of Methodological Quality of Basic Science Articles Published in Stroke