MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke | Zendy

Xinxin Yang | Zendy; Xuelian Tang | Zendy; Ping Sun | Zendy; Yejie Shi | Zendy; Kai Liu | Zendy; Sulaiman Hassan | Zendy; R. Anne Stetler | Zendy; Jun Chen | Zendy; KeJie Yin | Zendy

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MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke

Author(s) -

Xinxin Yang,

Xuelian Tang,

Ping Sun,

Yejie Shi,

Kai Liu,

Sulaiman Hassan,

R. Anne Stetler,

Jun Chen,

KeJie Yin

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.017284

Subject(s) - medicine , proinflammatory cytokine , antagomir , stroke (engine) , tumor necrosis factor alpha , blot , microrna , pathology , inflammation , biology , mechanical engineering , biochemistry , engineering , gene

Dysregulation of the miR-15a/16-1 cluster in plasma has been reported in patients with stroke as a potential biomarker for diagnostic and prognostic use. However, the essential role and therapeutic potential of the miR-15a/16-1 cluster in ischemic stroke are poorly understood. This study is aimed at investigating the regulatory role of the miR-15a/16-1 cluster in ischemic brain injury and insight mechanisms.

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