Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog | Zendy

Changjun Yang | Zendy; Kelly M. DeMars | Zendy; Jon C. Alexander | Zendy; Marcelo Febo | Zendy; Eduardo CandelarioJalil | Zendy

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Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog

Author(s) -

Changjun Yang,

Kelly M. DeMars,

Jon C. Alexander,

Marcelo Febo,

Eduardo CandelarioJalil

Publication year - 2017

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.117.016474

Subject(s) - medicine , prostacyclin , stroke (engine) , iloprost , anesthesia , mechanical engineering , engineering

Targeting the prostaglandin I 2 prostanoid (IP) receptor to reduce stroke injury has been hindered by the lack of selective drugs. MRE-269 is the active metabolite of selexipag showing a high selectivity toward the IP receptor. Selexipag has been recently approved for clinical use in pulmonary hypertension. We hypothesized that postischemic treatment with MRE-269 provides long-lasting neuroprotection with improved neurological outcomes in a clinically relevant rat stroke model.

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