Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke | Zendy

Alicia GarcíaCulebras | Zendy; Sara Palma-Tortosa | Zendy; Ana Moraga | Zendy; Isaac GarcíaYébenes | Zendy; Violeta DuránLaforet | Zendy; María Isabel Cuartero | Zendy; Juan de la Parra | Zendy; Ana L. Barrios-Muñoz | Zendy; Jaime DíazGuzmán | Zendy; Jesús M. Pradillo | Zendy; Marı́a A. Moro | Zendy; Ignacio Lizasoaín | Zendy

Open Access

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

Author(s) -

Alicia GarcíaCulebras,

Sara Palma-Tortosa,

Ana Moraga,

Isaac GarcíaYébenes,

Violeta DuránLaforet,

María Isabel Cuartero,

Juan de la Parra,

Ana L. Barrios-Muñoz,

Jaime DíazGuzmán,

Jesús M. Pradillo,

Marı́a A. Moro,

Ignacio Lizasoaín

Publication year - 2017

Publication title -

stroke

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.116.015956

Subject(s) - medicine , tlr4 , tissue plasminogen activator , extravasation , middle cerebral artery , ischemia , stroke (engine) , plasminogen activator , anesthesia , reperfusion injury , inflammation , thromboembolic stroke , pathology , mechanical engineering , engineering , atrial fibrillation

Hemorrhagic transformation is the main complication of revascularization therapies after stroke. Toll-like receptor 4 (TLR4) is implicated in cerebral damage and inflammation in stroke. This study was designed to determine the role of TLR4 in hemorrhagic transformation development after tissue plasminogen activator (tPA) administration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research